Most TCR Tg mice come from an artificially modified genomic construct. On the other hand, exogenous antigens in the context of MHC class II molecules are recognized by TCR on CD4 + T cells. Endogenously synthesized antigens are presented by MHC class I molecules and engage TCRs on CD8 + T cells. The direct interaction of a TCR with its cognate peptide-MHC complex mediates T cell development, activation, proliferation, differentiation, cytotoxicity, and cytokine production. A V(D)J recombination with an additional nucleotide addition or deletion results in a highly diverse TCR repertoire during T cell development and enables millions of antigens to be recognized. The TCR β- and δ-chains consist of V, diversity ( D), J, and C regions. TCR α- and γ-chains consist of variable ( V), joining ( J), and constant ( C) regions. TCRs are composed of highly diverse heterodimers and fall into two classes: TCR-αβ and TCR-γδ. Antigen recognition by T cells depends on the physical interaction between TCRs and antigen-major histocompatibility complex (MHC) molecules.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |